On November 15, 2001, about 5:54 a.m., eastern standard time, Canadian National/Illinois Central Railway (CN/IC) southbound train 533 and northbound train 243 collided near Clarkston, Michigan. The collision occurred on the CN/IC Holly Subdivision at a switch at the south end of a siding designated as the Andersonville siding. Train 533 had been operating in a southward direction through the siding and was traveling at 13 mph when it struck train 243. Signal 14LC at the turnout for the siding displayed a stop indication, but train 533 did not stop before proceeding onto the mainline track. Train 243 was operating northward on a proceed signal on the single main track about 30 mph when the trains collided. Both crewmembers of train 243 were fatally injured; the two crewmembers of train 533 sustained serious injuries. The total cost of the accident was approximately $1.4 million.