​​​​​​​​​​​​​This information is preliminary and subject to change.​​

On November 4, 2025, about 1714 eastern standard time (EST), United Parcel Service (UPS) flight 2976, a Boeing (McDonnell-Douglas) MD-11F airplane, N259UP, was destroyed after it impacted the ground shortly after takeoff from runway 17R at Louisville Muhammad Ali International Airport (SDF), Louisville, Kentucky. The 3 crewmembers aboard the airplane and 11 people on the ground were fatally injured. There were 23 others on the ground who were injured. Flight 2976 was a domestic cargo flight operating under the provisions of Title 14 Code of Federal Regulations (CFR) Part 121 from SDF to Daniel K. Inouye International Airport (HNL), Honolulu, Hawaii.

​In response to the accident, the NTSB traveled to SDF on November 5, 2025, and started the process of documenting the accident site, and collecting the perishable data necessary for the investigation. 

As part of the investigative process, the NTSB invited qualified parties to participate in the investigation. These included:

• the Federal Aviation Administration (FAA), 
• UPS, 
• The Boeing Company, 
• Independent Pilots Association (IPA), 
  
• General Electric (GE) Aerospace, and 
• Teamsters Airline Division.​